Oxycodone vs. Hydrocodone


Both Oxycodone and Hydrocodone are a type of drug that is prescribed as a temporary pain relief medication, such as any injury or surgery pain. Sometimes these drugs are also used to get relief from severe long-term pain, such as arthritis.

The active ingredients in Oxycodone are OxyContin, and Percocet and the active ingredients in Hydrocodone are Vicodin and Norco. These medicines can be taken consumed alone or in combination prescribed by the doctor. Both of these drugs have a quick response time, as the standard release version of Oxycodone and Hydrocodone takes about 30 min to 1 hour to show their effect, whereas, the immediate release version of Oxycodone takes about 10min to 15min to show its effect.

Similarities between Oxycodone and Hydrocodone

Oxycodone and Hydrocodone both are powerful and potent painkillers. These medicines are not too expensive compared to other pain killers available on the market. It is recommended to consume these drugs only after a consultation with a doctor and according to the doctors’ prescription. Oxycodone and Hydrocodone work by interfering with the signal processing of central nervous system, which delivers the sensation of pain to your brain. If any emergency situation arises, then it has been found that both of these medicines work with equal effectiveness. It has been found by the researchers that, in the event of pain, which is caused by fractured bone, both of these painkillers works equally well.

Differences between Oxycodone and Hydrocodone

Initially, it may seem that Oxycodone and Hydrocodone both are the same pain killer, but there are certain differences between them.

These two drugs mainly differ in their side effects. Consumption of Oxycodone may show nausea, dizziness, loss of appetite, headache, constipation, and vomiting, dry mouth, itching and sweating. These side effects are less severe than the side effects of Hydrocodone. However, the patient should be careful of any overdose of these medicines as taking an overdose of these medications could affect your health negatively.

Oxycodone is used to get relief from any severe pain. It is prescribed by the doctor and is stopped by the doctor when there is no need for the drug. Oxycodone should not be consumed according to your need but consulting a doctor.

On the other hand, Hydrocodone is used to get relief from the pain that are caused by any chronic conditions, such as surgery or any accidental injury. Unlike Oxycodone, Hydrocodone has an effect of addiction on the patient, this is why it is crucial to stop taking Hydrocodone as soon as you doctor asks you to stop Hydrocodone medicines. However, it has been found that patients consuming hydrocodone have a more frequent constipation problem than the patients consumed Oxycodone.


Consumption of Oxycodone combined with other medicines is not necessary, as Oxycodone alone is enough. Whereas, Hydrocodone is prescribed with a combination of other drugs.

Prescription method

As Oxycodone has high potential, that’s why the chemist does not readily prescribe it. You can buy Oxycodone only if you have an original hard copy of the prescription. Whereas, Hydrocodone and combination drugs can be obtained either with an original hard copy or a faxed copy of the order.


You should consider few facts before consuming Oxycodone over Hydrocodone, such as if you have a weak stomach. As consumption of Oxycodone requires a strong stomach and more active metabolism. It can be said that 7.5 mg of Hydrocodone is equal to 5mg of Oxycodone.