Low Protein in Blood

eat-191902_1920The human body is roughly made out of 62% of water, 16% of protein, 16% of fat, 6% of minerals and about 1% of carbohydrates and other nutrients. The most important proteins in the body are globulins and albumin. Albumin is the most abundant protein in plasma, where the term hypoproteinemia is often equated with it. Given the many complications that bring hypoalbuminemia, it is important to maintain the proteins to its optimal levels. Another significant protein in the body called globulin is the part of the immune system which has a big role in the body’s defense. If their level is low, there are many severe complications and conditions that can affect humans’ life.

Symptoms Of Hypoproteinaemia

Muscles and the body need proteins for energy use where, during digestion, it breaks down the proteins into amino acids and help reintegrate the body. Every hormone that has a strong influence on human’s metabolism is a protein structure, meaning, it needs protein sources inside the plasma. Low protein diet plan is more common in developing countries, but it is also possible in poor diet selection.


Edema is a sign of a fluid accumulation inside the tissue and cavities inside the body. There are a lot of symptoms that can generate this kind of symptom, but one of the most common ones is low albumin level. Albumin is one of the most binding protein in serum, which binds the water in the blood. When albumin levels drop in the extracellular compartment, the colloid osmotic pressure is no longer sufficient to balance out the hydrostatic pressure. The fluid outputs from the blood vessels into the cells to establish an equilibrium. This causes the cells to bubble and the edema is formed. The signs of edema are mostly visible on the feet, abdomen, hands and ankles. The edema doesn’t have to be visible in a local character, sometimes it can be expressed in the form of gaining weight.

Muscle Wasting

Since the muscles are mostly protein structures, when the body is lacking in proteins, it breaks down the muscles leading to muscle wasting. The muscles start to feel sore accompanied with fatigue and cramping. Loss of muscle mass leads to muscle atrophy.


Presenting the main part of the immune system, globulins take part in protecting against infection. If the levels are low and there are no immunoglobulins and antibodies, the body is susceptible to the influence of microorganisms. This makes the body more prone to severe conditions and serious infections. It can be dangerous, leading to deathly diseases.

The Risk Of Haemorrhage

When the protein levels are low, they include also the proteins that control the blood clotting which is thrombocytes and coagulation factors. In the absence of them, it may result in bleeding in the smallest injuries.

Skin, Hair And Nail Alterations

Proteins are necessary for the renewal of cells. When lacking, the skin can be pale and sensitive to light, where it can easily burn. You may experience pronounced dryness of the skin, delayed wound healing, and skin rash. They also influence on keratin inside the hair follicles and nail plates, where it may present in brown spots and white marks on the nail surface while the hair falls out easily and becomes brittle and dry. Containing about 90% of protein, hair requires an adequate level of proteins in the blood.

Other Symptoms Of Low Protein In Blood

  • Depression
  • Fatigue
  • Lethargy
  • Slow wound healing
  • Flaky skin
  • Abdominal pain
  • Nausea
  • Headaches

Causes Of Low Protein In Blood


If the diet plan that you’re taking is lacking in protein levels, you may suffer from malnutrition. If you don’t have enough intake of proteins, you may experience a life-threatening condition called Kwashiorkor. It affects mostly low-income regions and it expresses in edema. It is easily curable with a right meal plan and high protein intake.

Liver Diseases

Most proteins including hormones, enzymes, globulins and other protein structures are being synthesized in the liver. Conditions like cirrhosis and hepatitis can damage the liver in a stage where it produces less protein. It leads to serious symptoms like edema, ascites, and hemorrhage.

Renal Diseases

Most matter is being secreted through kidneys. They have a glomerular membrane which excretes selectively the fluid, keeping the proteins and electrolytes inside the body. In any conditions where the membrane is affected, the body can lose the protein through non-selective excretion, which leads to hypoalbuminemia. The kidney diseases can include glomerulonephritis and nephrotic syndrome, which has characteristic edema in the body. Albumin levels in the urine can be measured. When the concentration of the loss goes above 30mg/day, edema starts to form.


When the body isn’t capable of nutrients absorption, it can lead to a lack of protein. The food travels through the digestive system, but little of that is used. The body can be unable to break down the food, leading to losing of sugar, proteins, and fat. It is expressed in weight loss and malnutrition. One of the diseases that can lead to malabsorption is Celiac’s disease which is due to gliadin intolerance or it could be lactose intolerance as well.

Remedies For Low Protein In Blood

High Protein Intake

Your body requires about 8 grams of protein per kilogram of your body weight. If you are having some diet or do not eat well, you should incorporate every type of nutrients in optimal level to have a healthy body. You can divide your body weight by 2.2 and multiply by 0.8 to count the necessary grams of protein that you should intake. You should eat food rich in protein like fish, red meat, chicken. You should ingest legumes and nuts as well.

Avoid Alcohol

Avoid consuming alcohol and other substances that can cause liver damage and, consequently, protein deficiency. If you have any liver and kidney problems, you should do often check-ups to obtain a healthy life and prevent any disease.

Additional Conditions

Certain diseases can affect your body leading to protein loss. It can be cancer which uses the body’s nutrients leading to protein loss and cachexia. There are also conditions like hyperthyroidism which leads to accelerated metabolism and low albumin, which can lead to edema also. You should consult your doctor for a proper treatment.


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